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pyrrolidone
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Polyvinyl pyrrolidone K30 in the preparation of metronidazole

2020-03-13

Polyvinylpyrrolidone is a white or milky white powder, which can be dissolved in water to form a viscous gelatinous liquid or mixed with drug powder in a dry powder state. For hydrophobic drugs, it is suitable to use an aqueous solution of PVP as a binder. And can make the surface of the hydrophobic drug particles hydrophilic, which is beneficial to the dissolution of the drug and the disintegration of the tablet. Metronidazole is a hydrophobic substance. Adding polyvinylpyrrolidone can improve its wettability and accelerate the dissolution rate.

Metronidazole is a hydrophobic drug, and its compressibility is poor. Using PVP solution as a binder is beneficial to the uniform wetting of the particle surface, thereby increasing the tablet's adhesiveness [5]. In addition, PVP itself has hygroscopicity. As a binder, it increases the viscosity of the tablet, thereby improving the hardness and finish of the tablet.

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